Researchers at the University of Colombia have found special neurons in the brains of mice that ordered animals to eat.
According to RCO News Agency, Although many nutritional circuits in the brain play an important role in monitoring food consumption, the neurons in these circuits do not make the final decision to stop eating.
Quoted by Science Daily, The neurons identified by the University of Colombia are a new element of nutrition circuits and are located in the brain stem, the oldest part of the vertebral brain. This new discovery can help provide new treatments for obesity.
“These neurons are not similar to other neurons who are involved in Siri’s adjustment,” said Alexander Nectow. Other brain neurons are usually limited to the sense of food in the mouth, how to fill the intestine by the food, or feed the food. The neurons identified by our group are special in the sense that it seems that all the information is combined.
The decision to crack is a familiar phenomenon. “Every time we eat, this happens,” Necto continued. At one point when we are eating, we feel full and then we are full. Then, we get to the point where we think it’s enough.
How does the brain find that the body has eaten enough food and how it works with this information so that it does not eat? Other researchers had previously followed the effective cells in decision -making to the brain stem, but the clues ended there.
Necto and his group have used new single -celled methods to allow an area of the brain and the separation of different types of cells that have so far been difficult to distinguish from each other. “This method helps to see cells in the brain stem along with their molecular composition,” Necto said.
Researchers have engineered them to be active and active with light to see how neurons affect eating. When the neurons were activated by light, mice ate much smaller meals. The intensity of activation determined how fast the animals stop eating. “It is interesting that neurons do not just show an immediate stop, but help mice help to slow down their eating,” said Srikanta Chowdhury, a researcher at the project.
Necto and Chaodori also examined how other nutritional and hormones affect the neurons. They found that neurons were deactivated by a hormone that enhances appetite and were activated by a group of drugs used to treat obesity and diabetes called “GLP-1 agonist”. Experiments showed that these inputs help neurons track all the food eaten by the mouse.
“These neurons can smell, see it, feel it in the mouth and intestine, and examine all the intestinal hormones that are secreted in response to eating,” Necto said. Finally, they use all this information to decide how much time is.
Although special neurons were found in mice, Necto believes that their location in the brain stem indicates that humans are likely to enjoy them. “We believe that this is a new entry point to understand the meaning of being full, how to feel full and how to use it to end a meal,” he said. We hope that it can be used for future obesity treatments.
The study was published in the journal Cell.
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