Researchers made a surprising discovery in a comprehensive 40-month study. They found that the inexpensive drug metformin, commonly prescribed to treat type 2 diabetes, could dramatically slow the aging process in male monkeys. This drug has been particularly effective in delaying the damaging effects of aging on the brain.
According to the scientific news department of Tekna Technology Media, the results of this study, published in the prestigious journal Cell, indicate that metformin may have a significant potential to increase healthy life expectancy in humans. The monkeys who received metformin daily in this study showed much better brain function than the control group, and their neural activity was more similar to that of younger monkeys. In addition, this drug has positive effects on other organs, including the liver, kidney, skin, and lungs, and has slowed down the aging process in them.
Researchers believe that metformin protects cells from damage caused by aging by activating a protein called NRF2. NRF2 protein plays an important role in fighting inflammation and oxidative stress, both of which are considered to be the main factors of aging.
According to the promising results of this research, researchers have decided to conduct more extensive clinical studies on humans. Currently, a clinical trial with the participation of 120 people is underway, in which the effectiveness of metformin in slowing down the aging process in humans is investigated. This trial is being implemented in collaboration with Merck Pharmaceuticals, the developer of Metformin. Discovering the anti-aging effects of metformin is an important step towards the development of effective treatments to deal with aging and related diseases. Considering the increase in life expectancy around the world, the need for solutions to maintain health and quality of life in old age is felt more than ever.
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