Researchers say men are more at risk for Parkinson’s disease, and we can finally know the reason.
According to RCO News Agency, The risk of Parkinson’s disease in men is twice as high as women, and new research points to a potential reason that a protein in the brain is the cause of it.
Pink1 protein is not usually a threat and is important in regulating cellular energy consumption in the brain. However, new research shows that in some cases Parkinson’s immune system confuses Pink1 with the enemy and attacks the brain cells that express this protein.
According to the new study, led by a team of researchers from the Lahua Immunology Institute in California, Pink1 -related injuries caused by the T cells of the immune system are much wider and more aggressive in men’s brains than women.
“Sexual differences in the responses of T cells were very significant,” says Alessandro Sette, a immunologist from the Lahvia Immunology Institute. This safety response may be part of why we see the gender difference in Parkinson’s disease.
Researchers, using blood samples, patients with Parkinson’s patients tested the response of T cells in the blood to a variety of proteins previously linked to Parkinson’s, and found that the Pink1 was prominent.
In male patients with Parkinson’s, the research team noticed a six -fold increase in T cells compared to healthy brains that target Pink1’s brain cells. This amount increased by 0.7 times in women with Parkinson’s.
Some researchers had previously found that something similar is happening about T cells and alpha-synuclein protein. However, these reactions were not common in all brains with Parkinson’s, which led to more antigens (substances that stimulate immune responses).
As it always applies to this type of research, when more specialists know how to start a disease and how it progresses, new opportunities are created to find ways to stop injury.
“Now that we know why cells are targeted in the brain, we can potentially develop treatments to block these T cells,” says Cecilia Lindstam Arlehamn, a immunologist at the Lahuya Institute of Immunology.
In addition, the diagnosis of these Pink1 -sensitive T cells in blood samples can lead to the diagnosis of Parkinson’s early stages that help treat and support Parkinsonics patients.
“While we are still waiting for a treatment for Parkinson’s disease, the ongoing progress is being made in understanding the risk factors involved in its development and new approaches to deal with it,” Ardehman added.
“We need to understand more global analysis, disease progression and gender differences, taking into account all the different antigens, as well as the severity of the disease and the post -illness time,” he said.
This study is published in the Journal of Clinical Investigation.
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(Tagstotranslate) Parkinson’s
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