The role of vitamin D in the control of prediabetes in women – | RCO News Agency

According to the , citing the Presidential Vice President for Science, Technology and Knowledge-Based Economy, the doctoral thesis of Ruqieh Molanigol, entitled “Research on the relationship between the omentin gene polymorphism and dietary patterns and vitamin D status and its interaction with vitamin D supplementation on metabolic factors and obesity indicators in women with prediabetes, was carried out with the guidance of Maryam Rafraf and the support of the National Science Foundation of Iran.”

This study was designed and implemented with the aim of explaining the relationship between omentin gene polymorphism, dietary patterns, and vitamin D status, and investigating the interaction effect of vitamin D supplementation on metabolic indices, serum omentin levels, and obesity indices in women with prediabetes. The leader of this project has a doctorate in nutrition science from Tabriz University of Medical Sciences.

In the first phase of this study, 204 women aged 18 to 65 years with pre-diabetes, with a body mass index between 18 and 40 kg/m2, were included in the research using available sampling method. At this stage, the questionnaire of personal characteristics and physical activity was completed for all participants and anthropometric evaluations were performed. Also, in order to determine the food patterns, the food intake of the subjects was investigated at the beginning of the study using the food frequency questionnaire.

In the continuation of the first phase, venous blood samples were taken from all participants to determine the Val109Asp polymorphism of the omentin gene and to measure the serum level of vitamin D in order to analyze the relationship between genetic status, nutrition and the level of this micronutrient.

The second phase of this research was conducted as a randomized, controlled and double-blind clinical trial. Based on the data obtained from the first phase, the participants in each of the genotypes of the omentin gene polymorphism were randomly assigned to two groups receiving vitamin D supplements and the placebo group. People in the intervention group took vitamin D supplement with a dose of 50,000 units and the control group took a placebo including sunflower oil every two weeks for 12 weeks.

At this stage, before and after the supplementation period, fasting blood samples were taken from all subjects to measure metabolic indices and serum levels of vitamin D and omentin. Also, the anthropometric indicators, physical activity level and food intake of the participants before and after the intervention were recorded and analyzed.

The results of this study show that identifying the relationship between omentin gene polymorphism genotypes, dietary patterns, and vitamin D supplementation can help provide appropriate and personalized approaches in controlling prediabetes and reducing complications related to it. Based on this, the design of targeted educational and nutritional interventions, including the recommendation of specific dietary patterns and the use of vitamin D, can be tailored to the genotypes associated with prediabetes and increase the effectiveness of prevention and control programs for this disease.