According to Mehr news agency, citing New Atlas, previously researchers had tried to transfer a type of antibiotic called Narasin using nanoscale drug delivery stimuli and treat acne by combining microneedle patches and ultrasound.
Now, a group of researchers from Shenzhen Tsinghua International Graduate School, in collaboration with institutions from all over China, have developed a new platform for the simultaneous delivery of hydrophilic and hydrophobic drugs directly to the skin.
The main advantage of this method is to provide a quick and effective treatment for acne; A multifaceted disease that requires a combination of several different treatments. This method also avoids the use of oral medications that are associated with side effects.
In this study, the researchers integrated hollow bubble structures into dissolvable microneedles on a patch. This patch can be used to treat the desired area of the skin, without leaving any sharp and dangerous residue. The aforementioned patch is made of hyaluronic acid and allows filling different parts of the microneedle with various drugs; A capability that is of key importance for the treatment of this complex disease.
Each of these drugs has different properties and can be released at different rates. For example, hydrophilic anti-inflammatory agents are placed in the main body of the patch, hydrophobic antibacterial compounds in the walls of the bubbles, and an exfoliating agent in the base layer. In this way, active elements such as salicylic acid, pionin and dipotassium glycyrrhizinate are precisely transferred to the areas with acne in the skin and the effectiveness of the treatment increases.
Researchers tested this treatment method on mice. Bubble microneedle patches were used once daily for three days and the results showed that swelling, bacterial load and pro-inflammatory cytokines were significantly reduced. Also, the tiny holes made by the patch needles on the skin disappeared within five minutes without causing any damage or swelling.
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