According to RCO News Agency, a group of researchers Schools Tehran University of Technology, under the supervision of Dr. Ali Masoudinejad, a member of the Faculty of Engineering Sciences, with the cooperation of Dr. Hamid Taherkhani and Azadeh Kavianfardoctoral students of Kish International Campus, in a series of researches published in the international journals of Springer & Nature publications, the complex relationships between Microbiome lung, Epigenetics and have revealed the role of probiotics in the control of chronic obstructive pulmonary disease (COPD).
Member of the Faculty of Engineering Sciences in this load He said: These studies show the changes made in Microbiome The lungs remain affected by smoking, even after quitting, and through changes epigeneticaffect the function of the immune system and inflammation. Also, the bacterial balance in the lung plays a decisive role in the health and severity of lung diseases. In patients with COPD, the change in the composition of bacteria, especially the increase of pathogenic species such as Staphylococcus and Pseudomonas and the decrease of beneficial bacteria, causes the exacerbation of symptoms and increases the risk of mortality.
Masoudinejad added: Our results show that instead of removing bacteria, the microbial balance of the lung should be restored. The use of beneficial bacteria or probiotics can be a new way to control and even prevent the exacerbation of lung diseases.
Pointing out that this study shows that beneficial bacteria such as Lactobacillus and Bifidobacterium can play a therapeutic and preventive role in controlling lung diseases by modulating inflammation and immune response, he said: the use of probiotics in the future can be used as a new approach in personalized medicine for lung patients.
teacher Schools By stating that this research team has identified the complex relationships between bacteria and their function in different stages of COPD by using machine learning models, fuzzy logic and analysis of metabolic networks of bacteria, he added: Also, the role of microbial metabolites, especially short chain fatty acids (SCFAs), in modulating immune and inflammatory responses was determined. The simulation of metabolic networks of bacteria in the lung showed that during periods of disease exacerbation, microbial diversity decreases and pathogenic bacteria increase.
The head of this research team called the identification of key bacteria (Keystone genera) in different stages of the disease as one of the important findings of this research and said: The results showed that as the severity of the disease increases, the structure of microbial networks becomes more complex and some useful bacteria such as Lactobacillus and Bifidobacterium can play a protective role against the exacerbation of the disease. These two bacterial genera as candidates probiotic Potential for improving lung health and preventing disease recurrence have been suggested.
According to these researchers, strengthening Microbiome Lung through indigestible food or supplements probiotic It can help increase the production of beneficial metabolites such as SCFAs, thereby improving immune system function and reducing inflammation.
In the end, Dr. Masoudinejad emphasized: understanding the interaction between lung bacteria and the mechanisms epigenetic The body could revolutionize the future of personalized therapies. In this approach, instead of invasive treatment, we return our body to biological balance by using machine learning knowledge and probiotics.
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