New weapon against HIV; Nanoparticles that deceive the hidden virus – | Iranian and world news

According to the Mehr Reporter, the HIV virus is capable of being embedded within a specific type of white blood cells called CD3+ T (auxiliary cells); The condition in which the virus genome remains in the cell but does not produce any protein. This virus hideout causes parts of the virus to remain in the body even with the common antiviral treatments (ART) and re -activate the drug.

This research team managed to design a lipid nanopard called LNP X that carries MRNA and specifically targets CD3+ T cells at rest. These cells, which are difficult to access, are the location of the virus in the phase.

The key point in this technology is that the designed MRNA codes the initial part of the HIV TAT protein; Protein that plays a key role in activating viral genes. Thus, after the MRNA enters the cell, the latent virus begins to express the gene and becomes identifiable to the immune system.

In tests performed on CD3+ T cells extracted from patients with HIV, LNP X nanoparticles succeeded in without unwanted cell activation or creation Toxicity At the efficiency of over 5 %, bring the MRNA into the cells.

Researchers also showed that the system is capable of carrying CRISPR activation tools. This provides a way to targeted viral and host genes and will have extensive applications in T cell -based treatments.

One of the interesting findings of this study is that the high performance of the LNP X is due to unique features in delivering genetic content rather than recovering in common mechanisms such as “escaping. Endosome” This shows that the precise design of the formulation and the selection of molecules Caspusped They play a key role in the performance of this technology.

Previously, compounds called “reverse factors Commune(LRAS) was used to activate the latent virus, but these compounds were often not specific, Toxicity They have systemic and have not been able to reduce viral tanks effectively. In contrast, the LNP X has shown that it can play a similar role with high precision, proper safety and high efficacy.

Researchers have emphasized the high potential of the technology, saying that further investigations are essential to determining the optimal dose, biological distribution and safety in clinical environments. If successful, this technology can open a new path to HIV’s hidden treatment and perhaps other chronic viral diseases.

The results of this study are published in the reputable journal Nature Communications.