Results of a research project on the impact of diabetes on infertility – | Iranian and world news

Cyrus Jalili, a professor at the Kermanshah University of Medical Sciences, in a research project with the support of the National Iranian Science Foundation, examined the impact of high blood glucose conditions on molecular indicators related to sex cell function in women, according to .

Jalili, pointing out that type 2 diabetes is one of the most important causes of reproductive disorders in women, said the disease can cause folliculogenic, premature follicular atrophazation, non -ovulation and even spontaneous abortion. Granulosol cells play a key role in the ovary responsible for the production of estrogen and progesterone as well as regulating the growth of follicles and ovulation process.

“These cells are not only involved in the production of sex hormones, but also help the development of oocytes by secreting growth factors,” he said. But under diabetes -related hyperglycemia, the function of these cells is impaired and cellular stress, steroidogenes, and apoptosis increase.

According to the researcher, the effect of a biological compound on steroidal molecular indicators, endoplasmic network stress, and programmed cell death in high blood sugar conditions were investigated. The findings showed that this compound can protect the function of granulosic cells against damage caused by hyperglycemia.

At the end, Jalili said: Given the high prevalence of diabetes and its impact on women’s infertility, it is important to identify the factors affecting the improvement of sex cell function, and if the results are proved in clinical studies, the treatment of this compound can be hoped in the future.