This protein compound is vital for male fertility

According to RCO News Agency, The human body is full of controls and balances that guarantee the growth, development and performance of all its various systems. Japanese researchers have announced the discovery of a new protein interaction that regulates sperm growth.

Quoted by Asia Research News, The research group consisting of several institutes led by the University of Osaka University found that the interaction between two specific proteins is very important to ensure the proper growth of sperm cells.

Sperm formation is a very complex process that involves many changes. Disruption in this process at anywhere can lead to the production of inefficient sperm and infertility. “Abnormal sperm formation disrupts its ability to fertilize egg cells,” said Yuki Kaneeda, a senior researcher at the project. Although some of the genes that are essential for sperm are identified, there are still many points about the molecular mechanisms of this complex process.

To investigate the factors that may affect sperm formation, the researchers disrupted the expression of the “Tex38” protein in mice and found that the head of the resulting sperm bent over and infertility. Then, they examined why the removal of this protein has such a strong effect by examining other proteins in interacting with them.

“The results of the research were significant,” said Masahito Ikawa, a researcher at the project. We found that the Tex38 interacts with the “ZDHC19” protein. Removing each protein leads to sperm deformation, and if one of the proteins is not present, the other is expressed at much lower levels.

“Our findings show that Tex38 and ZDHC19 form a vital combination of sperm growth,” Chana said. This compound regulates proteins that are essential for the production of functional sperm with proper morphology.

Since the form and structure of sperm are key elements of sperm performance, the findings of this study provide important information about the causes of male infertility.

The research will soon be published in the journal PNAS.

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