According to RCO News Agency, quoted from University of Tehran, in the form of Mehsa Kalanter’s doctoral thesis at Tehran University, in collaboration with Iranian professors and France‘s Sorbonne University, an electrochemical device for rapid and accurate detection of biomarkers. sepsis (CRP) was designed and built.
Ali Hossein Rezayan vomitProfessor of the Department of Nanobiotechnology and biomimetic Faculty of Biological Sciences Engineering, by announcing this, said: sepsis It is an emergency and life-threatening condition that occurs when the body reacts violently and out of control in response to an infection, and this reaction causes damage to the body’s own tissues and organs. sepsis One of the most important causes of death in hospitalized patients is due to rapid progress and symptoms non-specificIts timely diagnosis is considered a vital challenge. This disease affects more than 48 million people worldwide every year and imposes a heavy burden on health systems.
The professor of nanobiotechnology department added: In this research, an electrochemical biosensor Microfluidic based on Aptamer It was designed, built and evaluated that the early detection capability of CRP marker in the early stages sepsis has the The thin layer electrodes of this system using the simple and low-cost shadow mask method on the substrate Polymethyl methacrylate were produced
Regarding the method of conducting this research, he stated: “A small-scale system (2 x 3 cm) including three working, auxiliary and reference electrodes was made and coated with titanium/gold and titanium/silver nanometer layers, respectively. The accuracy of the manufacturing process and the quality of the layers through various methods characterization Confirmed.
Rezayan said: The evaluation of the performance of the biosensor in human serum samples showed that this system, while eliminating costly steps Photolithographyin terms of sensitivity, detection limit and selectivity in identifying biomarkers related to sepsis Provides competitive performance.
It should be mentioned that this achievement, which is also supported by the results of simulation analysis, can lay the foundation for the development of fast, low-cost and portable diagnostic tools for the clinical management of patients with sepsis and open a new way to improve the quality of care and treatment in hospitals and diagnostic centers.
Among the achievements of this dissertation, we can publish two articles in prestigious international journals such as ACS Omega and Clinica Chimica Acta, register a national patent, a Persian article and present a speech at the 20th International Chemistry Symposium. electrolysis (ISEAC 20) in the city Changchun 2025, China pointed out.
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