According to the , citing the Presideial Vice Preside for Science, Technology and Knowledge-Based Economy, the doctoral thesis of Ruqieh Molanigol, eitled “Research on the relationship between the omein gene polymorphism and dietary patterns and vitamin D status and its ieraction with vitamin D supplemeation on metabolic factors and obesity indicators in women with prediabetes, was carried out with the guidance of Maryam Rafraf and the support of the National Science Foundation of Iran.”
This study was designed and implemeed with the aim of explaining the relationship between omein gene polymorphism, dietary patterns, and vitamin D status, and investigating the ieraction effect of vitamin D supplemeation on metabolic indices, serum omein levels, and obesity indices in women with prediabetes. The leader of this project has a doctorate in nutrition science from Tabriz University of Medical Sciences.
In the first phase of this study, 204 women aged 18 to 65 years with pre-diabetes, with a body mass index between 18 and 40 kg/m2, were included in the research using available sampling method. At this stage, the questionnaire of personal characteristics and physical activity was completed for all participas and ahropometric evaluations were performed. Also, in order to determine the food patterns, the food iake of the subjects was investigated at the beginning of the study using the food frequency questionnaire.
In the coinuation of the first phase, venous blood samples were taken from all participas to determine the Val109Asp polymorphism of the omein gene and to measure the serum level of vitamin D in order to analyze the relationship between genetic status, nutrition and the level of this micronutrie.
The second phase of this research was conducted as a randomized, corolled and double-blind clinical trial. Based on the data obtained from the first phase, the participas in each of the genotypes of the omein gene polymorphism were randomly assigned to two groups receiving vitamin D supplemes and the placebo group. People in the ierveion group took vitamin D suppleme with a dose of 50,000 units and the corol group took a placebo including sunflower oil every two weeks for 12 weeks.
At this stage, before and after the supplemeation period, fasting blood samples were taken from all subjects to measure metabolic indices and serum levels of vitamin D and omein. Also, the ahropometric indicators, physical activity level and food iake of the participas before and after the ierveion were recorded and analyzed.
The results of this study show that ideifying the relationship between omein gene polymorphism genotypes, dietary patterns, and vitamin D supplemeation can help provide appropriate and personalized approaches in corolling prediabetes and reducing complications related to it. Based on this, the design of targeted educational and nutritional ierveions, including the recommendation of specific dietary patterns and the use of vitamin D, can be tailored to the genotypes associated with prediabetes and increase the effectiveness of preveion and corol programs for this disease.
