Discovery of a gene that regulates the size of body cells – | RCO News Agency

According to Mehr news agency, quoted from InterestingEngineeringResearchers have long been puzzled about how cells grow sufficiently are. Too small or too large cells may cause dangerous diseases, but a genetic key beyond This balance has always remained ambiguous.

Now researchers have claimed are who found this mysterious key are. A group of researchers at SickKids Hospital found a gene in the non-coding genome for the first time. are which directly controls cell size.

This discovery is the way researchers understand growth on the surface It changes the biological foundation and the old idea that D itE Non-coder or the same D itE It challenges the redundant has little functional role. The mentioned research showed a RitE A long non-coding gene called CISTR-ACT acts as a master regulator of cell size, affecting how large or small cells are in different tissues.

CISTR-ACT to the non-coding genome, unlike conventional genes that code for proteins E It belongs to about 98% of D itE It forms a human being. Until recently, researchers did not understand the correctness of these areas Genomics did not have

Philip Mass Sick Kids senior researcher in this load He says: Our research showed RitEHi Long non-coding and non-coding regions of the genome may drive important biological processes, including regulation of cell size.

He further added the first group RitE identified non-coding genes that directly affect cell size.

CISTR-ACT has previously been associated with Mendelian diseases and chondral abnormalities, but its role in regulating cell growth remained unknown. Mendelian diseases are called disorders based on the laws of inheritance Mendel They are passed from parents to children

Researchers to discover this function of genetic engineering tools CrisperCass 9 and combined Cas13 with computational bioidentification. The results showed that CISTR-ACT in both levels of D itE and RitE It works and affects genes involved in cell growth and structure.