According to Mehr news agency, quoted from IerestingEngineeringResearchers have long been puzzled about how cells grow sufficiely are. Too small or too large cells may cause dangerous diseases, but a genetic key beyond This balance has always remained ambiguous.
Now researchers have claimed are who found this mysterious key are. A group of researchers at SickKids Hospital found a gene in the non-coding genome for the first time. are which directly corols cell size.
This discovery is the way researchers understand growth on the surface It changes the biological foundation and the old idea that D itE Non-coder or the same D itE It challenges the redunda has little functional role. The meioned research showed a RitE A long non-coding gene called CISTR-ACT acts as a master regulator of cell size, affecting how large or small cells are in differe tissues.
CISTR-ACT to the non-coding genome, unlike conveional genes that code for proteins E It belongs to about 98% of D itE It forms a human being. Uil recely, researchers did not understand the correctness of these areas Genomics did not have
Philip Mass Sick Kids senior researcher in this load He says: Our research showed RitEHi Long non-coding and non-coding regions of the genome may drive importa biological processes, including regulation of cell size.
He further added the first group RitE ideified non-coding genes that directly affect cell size.
CISTR-ACT has previously been associated with Mendelian diseases and chondral abnormalities, but its role in regulating cell growth remained unknown. Mendelian diseases are called disorders based on the laws of inheritance Mendel They are passed from pares to children
Researchers to discover this function of genetic engineering tools CrisperCass 9 and combined Cas13 with computational bioideification. The results showed that CISTR-ACT in both levels of D itE and RitE It works and affects genes involved in cell growth and structure.
