According to RCO News Agency, quoted from University of Tehran, in the form of Mehsa Kalaer’s doctoral thesis at Tehran University, in collaboration with Iranian professors and France‘s Sorbonne University, an electrochemical device for rapid and accurate detection of biomarkers. sepsis (CRP) was designed and built.
Ali Hossein Rezayan vomitProfessor of the Departme of Nanobiotechnology and biomimetic Faculty of Biological Sciences Engineering, by announcing this, said: sepsis It is an emergency and life-threatening condition that occurs when the body reacts violely and out of corol in response to an infection, and this reaction causes damage to the body’s own tissues and organs. sepsis One of the most importa causes of death in hospitalized paties is due to rapid progress and symptoms non-specificIts timely diagnosis is considered a vital challenge. This disease affects more than 48 million people worldwide every year and imposes a heavy burden on health systems.
The professor of nanobiotechnology departme added: In this research, an electrochemical biosensor Microfluidic based on Aptamer It was designed, built and evaluated that the early detection capability of CRP marker in the early stages sepsis has the The thin layer electrodes of this system using the simple and low-cost shadow mask method on the substrate Polymethyl methacrylate were produced
Regarding the method of conducting this research, he stated: “A small-scale system (2 x 3 cm) including three working, auxiliary and reference electrodes was made and coated with titanium/gold and titanium/silver nanometer layers, respectively. The accuracy of the manufacturing process and the quality of the layers through various methods characterization Confirmed.
Rezayan said: The evaluation of the performance of the biosensor in human serum samples showed that this system, while eliminating costly steps Photolithographyin terms of sensitivity, detection limit and selectivity in ideifying biomarkers related to sepsis Provides competitive performance.
It should be meioned that this achieveme, which is also supported by the results of simulation analysis, can lay the foundation for the developme of fast, low-cost and portable diagnostic tools for the clinical manageme of paties with sepsis and open a new way to improve the quality of care and treatme in hospitals and diagnostic ceers.
Among the achievemes of this dissertation, we can publish two articles in prestigious iernational journals such as ACS Omega and Clinica Chimica Acta, register a national pate, a Persian article and prese a speech at the 20th Iernational Chemistry Symposium. electrolysis (ISEAC 20) in the city Changchun 2025, China poied out.
