Researchers at the Indian Institute of Science have inveed a metal -based syhetic nanoteme that can help preve irregular blood clots caused by diseases such as lung embolism.
According to RCO News Agency, Blood cells called “platelets” under normal conditions are usually activated when the blood vessel is damaged. Platelets join together to form clots that protect the vein. This process called “bloodstream” or “hemostasis” coains a complex sequence of protein ieractions and is initiated by chemical signals such as “thrombin” and “collagen”.
Quoted by Azo Nano, In diseases such as cuvid-1 or lung embolism, these signal pathways may develop defects. This leads to increased oxidative stress and increased levels of oxygen activated species, which leads to excessive activation of platelets. As a result, many clots may form in blood vessels and lead to “thrombosis”, which is one of the main causes of disease and death.
To solve this problem, a team of researchers from the Indian Institute of Science (IISC) led by Professor Ghvindasamy Mugesh of the Institute’s Departme of Physics and Mineral Chemistry inveed nanomaterials that imitate natural aioxida enzymes. These factors called “nanoteme” help regulate the surface of the active oxygen species and preve excessive platelet activation and reduce the risk of excessive clot formation.
Researchers used corolled chemical methods to create active nanomaterials in various sizes, shapes and structures. Then, they extracted platelets from human blood and used chemical signals to the active stage to investigate what quality nanotemes preve excessive platelet accumulation.
The research group found that vanadium peoxide (V2O5) are the most effective examples. These nanotechnology imitates the function of glutathione peroxidase, which is a normal aioxida enzyme and reduces oxidative stress. Sherin Gr, a doctoral stude at the Indian Institute of Science and senior researcher, said: “The acquisition of a net shape of nanotechnology with positive oxidation of five vanadium oxides was challenging.” This was importa because the positive oxidation state of four is toxic to the cells.
“Unique chemistry of vanadium metal is very importa because oxidation-reduced reactions that reduce the surface of the active oxygen species are formed on the nanomaterial surface of the vanadium,” Mogash said.
Scieists tested the nanoteme in mice with lung embolism and found that it reduces thrombosis and improved survival. Also, they monitored the weight, behavior, and blood markers of the animals for five days after treatme and did not see any harmful effects.
Medications that are currely used to treat thrombosis can increase the risk of bleeding. “Unlike conveional drugs that ierfere with homeostasis, nanotemes do signal adjustme and do not cause natural blood clotting disorder,” said Bidare Sharathbabu, a doctoral stude at the Indian Institute of Science and researchers. This means that nanotemeles do not have the complications of bleeding, which is the main concern for curre treatmes.
The research team is now iended to investigate whether their nanotechnology can also help preve ischemic stroke caused by blockage of blood vessels.
They said: “We hope for human clinical experimes because we have done our tests with human platelets and they have been effective.”
The study was published in the journal Angwandte Chemie.
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(tagstotranslate) nanotechnology (T) Blood clot
