The discovery of a 5 -year genetic mutation that protects humans from AIDS virus

According to RCO News Agency, 5 % to 5 % of the Danish population carry a genetic mutation that can make them resistant or even safe. This information is used to develop new treatments for the virus.

Quoted by York Elert, So far, it was unclear where and when it happened, but a team of Copenhagen University researchers have now solved this genetic puzzle using advanced DNA review technology.

Professor Simon Rasmussen, a professor at the University of Copenhagen, said: “It turned out that the mutation was created in a person who lived between 5 and 5 years ago in an area near the Black Sea. HIV is a relatively new disease and is less than 5 years old. Therefore, it is almost random and attractive that a genetic mutation over thousands of years ago also protects humans from a new virus such as HIV.

Researchers first mapped it by analyzing the genetic material of 5 living persons around the world to determine the location and timing of this mutation. Then, they developed a new method of artificial intelligence to identify the mutation in ancient DNA obtained from old bones.

Researchers examined data from more than 5 skeletons from early Stone to the Vikings era. “Looking at this large collection, we can determine where and when it happened,” said Kirsstine Ravn, a senior researcher at the project. For a period, there is not a completely jump; But suddenly it appears and spreads unbelievable rapidly. When we combine this with our knowledge of human migration at the time, we can also identify the area where the mutation originates.

Researchers were able to find a leap in a Black Sea region, all of whom are carriers of this generation, but why do many Danes carry a thousand -year -old genetic mutation that protect them from a disease that did not exist at the time?

Researchers believe that this mutation was rapidly and expanded. “People who made the leap were better to survive,” said Leonardo Cobuccio, a project researcher.

The interesting thing is that this change disrupts a safety gene. This seems a negative feature, but it is probably useful. A overly aggressive immune system can be fatal. Think of allergic reactions or severe cases of viral infections such as Kavid-1. In these cases, the immune system often causes damage to patients. With the transition of humans from hunter-hunting societies to agricultural communities that lived together, the pressure caused by infectious diseases increased and a more balanced immune system may be useful.

The study was published in the journal Cell.

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