Bowel Health Regulator Discovered – | Iranian and world news

A study showed that the pressure -sensing protein, known as Piezo1, plays an important role in supporting bowel health, according to . The findings of this study are likely to provide new methods for understanding and treating complex bowel disorders.

This protein acts like an internal sensor in flat intestinal muscle cells and helps to find out when and how the food is coat in the digestive system. The intestine is mechanically active. Its digestive path is constantly shrinking and released. This rhythmic contraction of flat muscle cells leads to food breakdown and nutrient absorption. Disorder in this process results in a range of intestinal motor disorders. But the question is how do muscle cells in the intestine understand when to contract?

Researchers at the universities of UCD Davis and USCA also tried to answer these questions during a series of experiments on model mice. They focused on Piezo1.

Piezo3 is known for tracking physical forces such as expansion and pressure. When the researchers genetically removed this protein from the flat muscle cells, its effects, including weight loss, delay in food transfer, and thinning of the intestinal muscle layer were quite clear. They have also identified significant disorders in the calcium signal that is essential for correct muscle contraction.

“The results were extraordinary,” said Baotista, a neurologist at the UCD Davis Pediatric Hospital and a senior researcher. Despite significant changes in the intestinal mobility of these mice, they lived like other ordinary mice. This indicates the complex nature of the intestine.

The study also showed that there was a Piezo3 protein inside the flat muscle cell that had not been observed before. “After we found out that Piezo1 was not only on the surface of the stretching sensor cells but also inside the cell, we were surprised,” said Martin J. Martin, another senior researcher. This process helps control the path of calcium ions, which are key factors in muscle contraction.

The internal position of the Piezo2 shows that it is likely to be involved in vital signaling mechanisms for appropriate motion rhythm and force produced during intestinal contractions.

“This research provides us with a completely new perspective,” Baotista says. Piezo۱ is probably one of the former unknown regulators for bowel health.