Researchers say one of the most common drugs prescribed and taken to corol diabetes significaly improves knee pain caused by arthritis.
According to RCO News Agency, A well -known diabetes drug significaly reduces knee arthritis pain.
A new study shows that a major diabetes drug reduces pain and stiffness and improves performance in overweight people with knee arthritis.
Effective reduction of pain and improveme of mobility may mean that people with this disease can delay the aggressive knee replaceme surgery.
Knee osteoarthritis (OA) affects hundreds of millions of people worldwide and can be a challenge for treatme, as effective treatme options are available.
More than half of paties with knee osteoarthritis are overweight or obese, which puts a lot of pressure on their knee joi and causes inflammation that both coribute to the progression of the disease.
Now in collaboration with the Faculty of Preveive and Medical Medicine of the University of Monash (Monash), the Menzies Institute of Medical Research at Tasmania University and the Rheumatology Departme at Alfred Hospital (Alfred), MetFormin, which is one of the primary treatmes for diabetes, can be reduced even in diabetes.
Professor Flavia Cicuttini, head of the rheumatology departme at Alfred Hospital and head of the musculoskeletal departme at the University of Monash and the author in charge of the study, said: “General practitioners are very familiar with metformin, which is a low -cost and safe drug.” In addition to other treatmes that people with diabetes, it can also be provided to paties with arthritis and has the poteial to delay knee joi replaceme before absolute need.
He added: “In people who consume metformin and have less knee pain and can have more physical activity, knee replaceme surgery can be delayed.”
Curre treatmes for painful knee arthritis focus on relieving symptoms and improving knee joi function.
In addition to pain relief drugs such as non -steroidal ai -inflammatory drugs (NSAIDS), non -surgical treatmes include exercise, weight manageme, physiotherapy and steroid injection io the joi.
Treatmes including surgery also varies from low invasive arthroscopy for removal or repair of damaged tissue to knee joi replaceme surgery.
The researchers selected four overweight and non -diabetic individuals over the age of 5 who had knee pain for 6 mohs or more and randomly divided them io two groups.
The treatme group took up to 5 mg of slow metformin pills daily for 6 mohs. Another group was given placebo with a similar appearance. The drug started at a dose of 5 mg daily and increased to 5 mg daily within 2 weeks to reduce gastroiestinal side effects.
Participas can use acetaminophen (paracetamol) for significa knee pain. Participas’ pain was initially assessed from “painless” (zero score) on one side to the “worst painful pain” (score 1) on the other.
The initial consequence of this study was the change in knee pain after 6 mohs of the feeling of basic pain. Secondary consequences also included basic changes in stiffness and joi performance and quality of life related to health.
Participas reported a 3.5 -poi reduction in knee pain for 6 mohs after consuming metformin for 6 mohs compared to a 3.5 -poi reduction in the placebo group.
The effect of this drug is generally considered average. While the effect cannot be considered “much”, the work here is still indicative of a significa difference between the two groups.
In addition to the less pain, people in the treatme group also reported significa improveme of stiffness and knee function compared to the placebo group. However, there was no significa difference between the two groups in terms of change in quality of life.
Side effects were reported in the consumer group (2 %) and placebo (2 %), but none of them were serious. The most common side effects include mild to moderate diarrhea and abdominal and gastroiestinal discomfort.
Researchers say the findings show that “metformin” can be used as part of the treatme of arthritis after discussion between the patie and the physician.
“Metformin” has been known so far and is currely used to treat diseases other than type 2 diabetes.
“Metformin” affects the knee in a variety of ways, including the effect of low -degree inflammation and other metabolic pathways that are importa in knee arthritis, “says Sykotini. This is a differe way to treat knee arthritis pain.
Metformin is safe and tolerable and is used safely in other non -diabetic conditions such as polycystic ovary syndrome. Metformin can be easily and safely provided using a remote health approach, as we did in our study. This means that it can be offered to all society.
Larger clinical trials confirm the reports reported in the prese study.
This study is published in the journal JAMA.
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