Unveiling of the role of hereditary genes in cancer and its treatment

According to RCO News AgencyUnlike most cancer research that focuses on acquired mutations throughout life, this study has studied millions of hereditary genes and their impact on protein activity in tumors.

These findings can transform the way the cancer is diagnosed and treated with the unique genetic background of each person and is a new approach to personalized cancer treatment.

According to STDs, a new international study led by Researchers at the Ican School of Medicine (ICahn) in Mount Sinai in collaboration with the Clinical Protoomic Tumor Analysis Company (CPTAC) at the National Cancer Institute in the United States has shown that our hereditary genes are born in Germ. Variants play a very important role in cancer compared to previous findings.

This is the first study to show how millions of hereditary genetic differences can affect the activity of thousands of proteins inside the tumors.

The researchers found data in more than 5 patients with 2 different types of cancer that a person’s hereditary DNA can determine how their cancer progresses and behavior.

Another definition of cancer treatment

These insights can transform cancer treatments. Most treatments today are developed by the genetic mutations found in the tumor itself.

This study shows that considering the inherited genetic background of the patient can also improve the diagnosis of cancers, how to evaluate them, and how to choose their treatment.

“Every person carries a unique combination of genetic varieties with a unique combination of genetic varieties, and these hereditary differences make our cells work unnecessary in life,” says Dr. Zeinab Gümüş, author of this study.

“Our findings show that the use of these genes is not just in this regard,” he said. They can play an active role in the formation of tumors, how they evolve, and even how they respond to treatment. This provides new facilities for new approaches to the treatment of cancer based on the patient’s hereditary genetic structure.

From somatic mutations to types of hereditary genes

So far, most of the cancer research has focused on “somatic mutations”, but researchers say that inherited types of “germine cells” are much greater than “somatic mutations” and their effect on cancer has not yet been well understood.

“Somatic mutation” refers to changes in the DNA that occurs in the cells of the body after birth. These mutations can occur due to environmental factors such as ultraviolet radiation or carcinogenic chemicals.

The researchers used an advanced technique called Prettidomics to enable them to check how specific inherited mutations regulate the structure, stability and function of proteins in cancer cells.

“Our study showed that DNA’s hereditary changes could affect the production and defining genes and modifying proteins in the tumors,” says Dr. Gomusush. These changes change their process.

“With the help of these findings, doctors can use a variety of ways to develop, progress and respond to cancer to treatments,” he said.

Researchers warn that the findings of this study are based on data from a predominantly European -based group, and further research is needed to ensure these insights are used in multidisciplinary populations.

Accurate person medicine

“This is a great step towards a precise medical science that takes into account the entire character of the individual,” says Myvizhi Esai Selvan, a senior author of this study and genomic lecturer at the Medical School in Monte Sina. In the development of cancer, hereditary genome determines the progression of the disease. These genes also help determine which mutations are important or how much a tumor may be aggressive or how the immune system will respond to.

The team is now investigating these insights in two areas:

Cancer therapy

Researchers, in collaboration with the Cancer Safety Centers at the National Cancer Institute, have examined why some patients respond well to Immuntherapy, while not for others. In this area, hereditary genetic differences can be a key element.

Predicting the risk of lung cancer

Researchers are developing computational models to predict the risk of lung cancer based on the individual’s hereditary genetic characteristics through the Health Exploration Program. These tools can speed up early detection.

This study is published in the journal Cell.

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