Mice that were born without the presence of a female rat using stem cells, have reached adulthood and reinstated reproduction at a scientific milestone.
According to RCO News Agency, A group of stem cell scientists successfully produced mice from two male parents who have reached maturity in an important event.
In a new study published in the journal Cell STEM CELL, researchers at the Chinese Academy of Sciences (CAS) overcome the important challenges that have prevented mono -gender reproduction in mammals.
Efforts in the past may cause fetal growth, but their growth has stopped at some point. According to a press release, this new approach focused on a specific set of genes.
Qi Zhou, the author of the study, says that since “role -playing genes” adjust the gene expression with unique features, scientists believe that they are an essential obstacle to single -gender reproduction in mammals.
Chinese researchers modified these genes using a variety of techniques that allowed them to create new and important fields in this field, making us one step to achieving something that was once impossible, creating a baby out of two. Gay parents got closer.
According to Hei Li, the author in charge of the study, this will help remove a number of restrictions on stem cell and reconciliation research.
Birth of Mice’s Babies of Two Father
In a study published in the journal Cell, the authors of the study raised the question whether the role of genes alone prevents the reproduction of two fathers in mammals.
Previous efforts using ovarian organoids failed to produce two paternal rats that had no defect in the carved genes.
“Even when making two maternal or two -father -in -law artificially, they do not grow properly and stop growing because of these genes,” Chi Zhou explained in a press release.
The researchers applied genetic modification to hundreds of engraved genes, including the jump of framework change, gene removal and regulatory editing. As a result, as stated in this study, they developed a strategy that effectively address the most severe developmental defects in two paternal fetus.
Researchers, in particular, targeted these genes, were able to produce children from two paternal parents by injecting the ESC supplement haploid cell nucleus and transferring the somatic cell nucleus (SCNT).
Only 4.3 percent of the fetuses grew until birth. Not all mice survive due to lasting growth defects until adulthood. Researchers say most of the cases that reached puberty still experienced abnormal growth and shorter life. They were also sterilized. However, this method also led to more sustainable stem cells.
Pluripotation in biological compounds describes the ability of some materials to create several distinct biological responses. Like the ability to distinguish between different cells in the case of powerful stem cells, power is described as something that has no fixed growth potential.
The results of this study, far from a complete science, showed that, however, the anomalies of the carving of the gene represent a fundamental obstacle to the reproduction of two paternal mammals.
Zhi-Kun Li, authors of the study, said: More reforms in carved genes can potentially produce healthy two-father mice capable of producing live gametes and lead to new therapeutic strategies for related diseases. , Facilitate.
Although the research team plans to conduct similar research on monkeys, they are now reliance on mice. They should continue to test the correction of engraved genes to create appropriate conditions for the natural growth of the fetus.
As the press statement said: Whether this technology is ultimately used to treat human diseases is still unclear.
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(tagstotranslate) Stem cell
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