Researchers have succeeded in neutralizing the effects of drugs in overdose with a new antibody

Researchers have developed a new antibody to treat drug overdoses that can target fentanyl and address its complications.

According to Tekna technology and technology news service, Californian researchers at the Scripps Institute were able to develop a new human antibody to solve the problem of overdose. This new substance can prevent overdose death by sticking to fentanyl and its various derivatives. Project leader Kim Janda says that developing this antibody as a new weapon in the future could reduce drug-related crises.

According to researchers, it is very difficult to treat overdose with drugs like fentanyl. Because this substance binds to Mu opioid receptors in the brain and makes treatment difficult. Currently, a substance called Nanoxane is used to treat overdose, which reduces the effect of this drug by binding to brain receptors. Of course, this article also faces limitations. For example, its duration of effect is very short and in some cases it cannot be effective on fentanyl derivatives. The researchers’ new antibody is a single-variable single-chain type that has a synthetic and small structure. One of the main features of this substance is binding to the antigen in the IgG antibody, thus it can reduce the effect of Fentonil.

Experiments conducted with this substance on mice showed that the new antibody can reverse the problems caused by overdose, such as respiratory failure, only after 15 minutes of injection.