A new study suggests that nitrogen oxide may cause quick relief to the disease with depression.
According to RCO News Agency, Depression affects millions of people around the world, and many are trying to find effective relief.
While standard therapies such as treatment and medications help some, almost a third of the patients fail. Traditional antidepressants often take weeks to operate and force many to endure long -term suffering while waiting for the result.
But what would be the faster relief?
New research suggests that nitrogen oxide, commonly known as “laughing gas”, may be a rapid replacement for the treatment of resistant depression.
Scientists at the University of Pennsylvania discovered a wonderful new mechanism behind the antidepressant effects of nitrogen oxide.
It seems that this multi -hundred -year -old anesthetic, which has long been used because of its sedative and anesthetic properties, is more than one drug for dentists and surgeons. The study shows that nitrogen oxide can provide a deep and urgent response in specific brain cells and provide a new hope for those who have struggled with traditional treatments.
Discovering the hidden mechanism of this drug
Historically, scientists believed that nitrogen oxide works by blocking NMDA receptors that exist in almost all brain cells and play an important role in managing pain and communication between neurons.
However, a group led by Dr. Cichon at the University of Pennsylvania discovered a different process. Their research identified the layer of five neurons deep in the gray matter of the area of the brain responsible for regulating emotions and behavior.
Wake bell for brain
The group, in collaboration with researchers at the University of Chicago and the University of Washington at St. Lewis, tested nitrogen oxide on mice in stressful conditions.
The mice inhaled the gas for an hour through the mask, which resulted in an unexpected reaction in them. Instead of calming the brain, nitrogen oxide activated the fifth layer neurons almost immediately.
“Most anesthetic medications calm the brain and then the effects of anesthesia are eliminated,” Cichun explained. But the drug activates those cells, and even after the gas is finished, the cells continue.
After treatment, the mice behaved better, moved more, and drank with freshwater desire, which was a sign of increased pleasure.
The researchers identified the SK1 potassium channels in the fifth layer neurons as a key factor. These channels usually allow potassium ions to leave the cells and calm them down. However, nitrogen oxide blocks these channels and keeps the neurons active and leads to rapid mood strengthening.
Quick relief but not a home -based solution
One of the three people with depression does not respond to standard antidepressants, and existing medications often take weeks to show their effects.
On the other hand, nitrogen oxide works almost immediately, and the results of those hours or even a full day remain. Human trials confirm that nitrogen oxide provides quick relief for patients with depression resistant to treatment.
But you should know that prescribing nitrogen oxide requires a trained medical specialist to use it to treat depression. Its possible side effects also include nausea and mask discomfort during inhalation.
Researchers are now investigating how long the effects of mood improvement remain and nitrogen oxide can help reset the brain for long -term relief.
If successful, a drug used for more than 5 years can bring a new hope for people who are struggling with severe depression.
This study is published in the journal Nature Communications.
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(tagstotranslate) Anti -dissemination drug (T) laughing gas
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