According to Mehr news agency, citing Interesting Engineering, Dr. Paivi Tamla and his group at the University of Helsinki focused on actinobacteria, a branch of bacteria that exists in soil and other environments. The global health crisis of antibiotic resistance has led to increased attention to marine actinobacteria as a possible source of new and effective antibiotics.
Actinobacteria provide many bioactive compounds, some of which are now used as antibiotics and other drugs, such as anticancer drugs and immune system modulators, according to Tamela.
70% of current antibiotics originate from Actinobacter soil, and most of terrestrial environments have not been investigated for antibiotic discovery. For this reason, researchers decided to study new molecules in the Arctic Ocean. They looked for compounds that would reduce the bacteria’s ability to cause disease or their infectivity.
They collected samples from the Arctic and examined their pathogenic properties using sophisticated laboratory techniques to analyze extracts of marine actinobacteria.
After months of research, researchers came across a natural compound that was able to inhibit the virulence of a dangerous strain of E. coli bacteria. We discovered a compound that inhibits the pathogenicity of E. coli (EPEC) without affecting its growth, as well as a growth-inhibiting compound, both found in Actinobacteria from the Arctic Ocean.
The mentioned compounds were extracted from 4 species of actinobacteria that were collected during research operations in the arctic sea in 2020.
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